Bioinformatic identification and analysis of Schistosoma japonicum adenine phosphoribosyltransferase.
- Author:
Zhong YANG
1
;
Wei HU
;
Jin SU
;
Li MA
;
Yi-xue LI
;
Zheng FENG
;
Dong-zhi WEI
Author Information
- Publication Type:Journal Article
- MeSH: Adenine Phosphoribosyltransferase; chemistry; genetics; Animals; Computational Biology; methods; Helminth Proteins; chemistry; genetics; Isoenzymes; chemistry; genetics; Models, Molecular; Phylogeny; Protein Conformation; Schistosoma japonicum; enzymology
- From: Journal of Southern Medical University 2007;27(3):272-275
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo identify adenine phosphoribosyltransferases in Schistosoma japonicum and analyze their structural features.
METHODSBased on the accessible transcriptome and proteomic data, the S. japonicum adenine phosphoribosyl transferases were identified using bioinformatics approaches including bi-directional homology comparison, domain search and phylogenetic analysis. Homology modeling was also performed to describe the structural features of the proteins.
RESULTS AND CONCLUSIONTwo homologue sequences of adenine phosphoribosyltransferase were obtained from S. japonicum, and the EST abundance, physico-chemical properties and three-dimensional structures of them were also acquired.
