Ecdysterone promotes wound healing in rabbits.
- Author:
Liang HOU
1
;
Xu WU
;
Wu-jun WANG
Author Information
- Publication Type:Journal Article
- MeSH: Administration, Topical; Animals; Ecdysterone; administration & dosage; Male; Rabbits; Random Allocation; Skin; drug effects; injuries; Treatment Outcome; Wound Healing; drug effects; Wounds and Injuries; drug therapy
- From: Journal of Southern Medical University 2007;27(3):312-314
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the efficacy of ecdysterone in promoting wound healing in rabbits.
METHODSTwenty-one New Zealand rabbits were randomized equally into 3 groups and in each rabbit, 4 separate full-thickness skin wounds were induced and treated with dexamethasone, ecdysterone and Yunnan white powder, or untreated, respectively. On day 3, 6, and 9, respectively, one group of rabbits were sacrificed and the local wound tissue was obtained for pathological examination.
RESULTSThree days after the operation, the 4 wounds in each rabbit did not show significant difference in the healing rate (P>0.05). On day 6, as was similar to day 9, ecdysterone and Yunnan white powder showed better efficacy in promoting wound healing than dexamethasone (P<0.01), the latter having similar effect with the control management (P>0.05), and that of ecdysterone was similar to Yunnan white powder (P>0.05). Pathologically, early stage of wound healing was characterized by exudation and hyperemia, and on days 6 and 9, ecdysterone and Yunnan white powder exhibited similar strong effect for shaping the granulation tissue and stimulating epithelial cell proliferation.
CONCLUSIONEcdysterone can obviously promote wound healing in rabbits, which may offer a clinical alternative for promoting wound healing.
