Expression of Girdin in brain tissues of Alzheimer's disease.

Longteng Liu; Ping Jiang; Di Cui; Jun DU; Lei HE; Jingjing Yao; Dongge Liu; E-mail:liudongge@sohucom

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Expression of Girdin in brain tissues of Alzheimer's disease.

Author: Longteng LIU ¹ ; Ping JIANG ¹ ; Di CUI ¹ ; Jun DU ¹ ; Lei HE ¹ ; Jingjing YAO ¹ ; Dongge LIU ² ; E-mail:liudongge@sohu.com.
Author Information

1. Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China.
2. Department of Pathology, Key Laboratory of Geriatrics, Beijing Hospital, Ministry of Health, Beijing 100730, China
Publication Type:Journal Article
From: Chinese Journal of Pathology 2015;44(5):301-304
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the expression of Girdin and its significance in Alzheimer's disease (AD).
METHODSFifty-nine autopsy cases from Department of Pathology, Beijing Hospital from January 1988 to December 2013, including 35 AD cases and 24 non-AD cases as control. Girdin and amyloid β-protein (Aβ) expression was evaluated immunohistochemically by EnVision method. The correlation between Girdin and Aβ was analyzed.
RESULTSGirdin expression was localized in the nucleus and/or cytoplasm. The expression rates of Girdin were 20.0% (7/35) in the AD group and 83.3% (20/24) in the non-AD group, respectively. The difference was significant (Yates's correction for continuity χ(2)=20.527, P<0.05). Girdin expression and Aβ deposition also correlated significantly (P<0.05).
CONCLUSIONSGirdin shows reduced expression in AD, and is correlated positively with Aβ deposition. This suggests that Girdin may play an important role in the occurrence and development of AD.