Immunohistochemical evaluation of mutant p53 protein over-expression in non-mucinous adenocarcinoma in-situ and invasive adenocarcinoma, NOS of lung.
- Author:
Yayan CUI
;
Jie ZHANG
;
Jiping DA
;
Honglei ZHANG
;
Dong CHEN
- Publication Type:Journal Article
- MeSH: Adenocarcinoma; metabolism; Adenocarcinoma in Situ; metabolism; Humans; Immunohistochemistry; Mutant Proteins; genetics; metabolism; Tumor Suppressor Protein p53; genetics; metabolism
- From: Chinese Journal of Pathology 2015;44(3):175-178
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the over-expression of mutant p53 protein in non-mucinous adenocarcinoma in-situ (NMAIS) and invasive adenocarcinoma, NOS of lung.
METHODSImmunohistochemical study for p53 protein was performed on 17 cases of NMAIS and 70 cases of invasive adenocarcinoma, NOS of lung. The difference in p53 over-expression between the two tumor subtypes was analyzed.
RESULTSThe over-expression of mutant p53 protein was observed in 0 case (0%) of NMAIS and 37 cases (52.9%) of invasive adenocarcinoma, NOS of lung. The difference was of statistical significance (P = 0.000).
CONCLUSIONMutant p53 protein over-expression may play a role in the progression of NMAIS to invasive adenocarcinoma, NOS.