Epigenetic research progress of anti-tumor drugs.
- Author:
Mou-ze LIU
1
;
Fa-zhong HE
1
;
Wei ZHANG
1
Author Information
1. Institute of Clinical Pharmacology, Hunan Key Laboratory of Pharmacogenetics, Central South University, Changsha 410078, China.
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents;
therapeutic use;
DNA Methylation;
Epigenesis, Genetic;
Histones;
genetics;
metabolism;
Humans;
MicroRNAs;
metabolism;
Neoplasms;
drug therapy;
genetics
- From:
Acta Pharmaceutica Sinica
2013;48(11):1629-1636
- CountryChina
- Language:Chinese
-
Abstract:
Epigenetic abnormalities not only associated with carcinogenesis, they may also influence the curative effect and prognosis of anticancer drugs through modifying pharmacokinetic genes related to drug absorption, distribution, metabolism, excretion and pharmacodynamic genes related to signaling pathways and targets. That drugs through regulating epigenetic factors pocessing anti-cancer effect is becoming a research hot spot. We summarized and analyzed the realtionship of DNA methylation, miRNA, and histone modification with antitumor drug effect, aiming at promoting rational use of antitumor drugs and providing new ideas on developing epi-drugs.
