Progress in the study of carbonic anhydrase inhibitors as potential anticancer drugs.
- Author:
Jia GUO
1
;
Feng-ran LI
1
;
Yang LIU
1
;
Mao-sheng CHENG
1
Author Information
1. Key Laboratory of Structure-Based Drugs Design and Discovery (Ministry of Education), Shenyang Pharmaceutical University, Shenyang 110016, China.
- Publication Type:Journal Article
- MeSH:
Antigens, Neoplasm;
metabolism;
Antineoplastic Agents;
chemistry;
therapeutic use;
Carbonic Anhydrase IX;
Carbonic Anhydrase Inhibitors;
chemistry;
therapeutic use;
Carbonic Anhydrases;
metabolism;
Humans;
Neoplasms;
drug therapy;
enzymology
- From:
Acta Pharmaceutica Sinica
2013;48(11):1637-1643
- CountryChina
- Language:Chinese
-
Abstract:
Carbonic anhydrase IX (CA IX) is a tumor associated protein which is able to be a potent anticancer target, since it is highly expressed in a multitude of carcinomas, while it is present in a limited number of normal tissues. This review focuses on its role in tumor physiology, the most recent three dimensional structure features of this enzyme which has recently been elucidated. In addition, we present recent advances in the development of small inhibitors able to target CA IX for therapeutic applications.
