Adsorption and release behavior of epirubicin hydrochloride on carboxylated single-walled carbon nanotubes.
- Author:
Rui LIN
1
;
Li-li LI
2
;
Jia HE
2
;
Lan-lan QIU
1
;
Hua HE
2
Author Information
1. Yancheng Health Vocational and Technical College, Yancheng 224005, China.
2. Division of Analytical Chemistry, China Pharmaceutical University, Nanjing 210009, China.
- Publication Type:Journal Article
- MeSH:
Adsorption;
Antibiotics, Antineoplastic;
chemistry;
Carboxylic Acids;
chemistry;
Drug Carriers;
Epirubicin;
chemistry;
Nanotubes, Carbon;
chemistry
- From:
Acta Pharmaceutica Sinica
2013;48(11):1710-1715
- CountryChina
- Language:Chinese
-
Abstract:
In this study, the adsorption behavior of epirubicin hydrochloride (EPI) on carboxylated single-walled carbon nanotubes (c-SWNTs) obtained by mixture acid treatment was investigated. The results indicated that the dispersion of c-SWNTs in water was obviously improved. The absorption of EPI on c-SWNTs came to equilibrium after 240 min and could be explained by pseudo-second-order model. Moreover, there were heterogeneous distribution of active sites onto c-SWNTs surface and the Freundlich isotherm model was better fit to describe the absorption precess of EPI on c-SWNTs. The absorption capacity of EPI on c-SWNTs increased obviously with the increasing pH and decreasing temperature. Compared with multi-walled carbon nanotubes, carboxylated multi-walled carbon nanotubes, SWNTs, c-SWNTs possessed higher absorption capacity for EPI. The controlled, targeted and sustained release of EPI from c-SWNTs-EPI could be instructive for the development of nano-carrier.
