A new indole alkaloid from the stems of Brucea mollis.
- Author:
Hui CHEN
;
M A SHUANG-GANG
;
Zhen-Feng FANG
;
Gui-Jie ZHANG
;
Shi-Shan YU
;
Xiao-Guang CHEN
- Publication Type:Journal Article
- MeSH:
Antineoplastic Agents, Phytogenic;
chemistry;
isolation & purification;
pharmacology;
Brucea;
chemistry;
Carbolines;
chemistry;
isolation & purification;
pharmacology;
Cell Line, Tumor;
Humans;
Indole Alkaloids;
chemistry;
isolation & purification;
pharmacology;
Molecular Structure;
Plant Stems;
chemistry;
Plants, Medicinal;
chemistry
- From:
Acta Pharmaceutica Sinica
2014;49(2):225-229
- CountryChina
- Language:Chinese
-
Abstract:
Eight compounds were isolated from the stems of Brucea mollis by various chromatographic techniques such as column chromatography on silica gel and Sephadex LH-20, and preparative HPLC, and their structures were elucidated as bruceolline O (1), 1-(1-beta-glucopyranosyl)-1H-indole-3-carbaldehyde (2), canthin-6-one (3), 11-hydroxycanthin-6-one (4), 9-methoxycanthin-6-one (5), 4-methoxycanthin-6-one (6), infractin (7), and beta-carboline-1-propionic acid (8). The cytotoxic activities of compounds 1-8 against HCT-8 and A549 human cell lines were determined, but none of them exhibited significant activity (IC 50 > 10 micromol x L(-1)). Among them, compound 1 is a new indole alkaloid, and compounds 2 and 5-7 were isolated from this plant for the first time.
