Progress in methodology of establishing physiologically based pharmacokinetic models.
- Author:
Yu-Wen JIN
;
Yue-Ming MA
- Publication Type:Journal Article
- MeSH:
Animals;
Biological Transport;
Computer Simulation;
Humans;
Models, Biological;
Pharmaceutical Preparations;
chemistry;
metabolism;
Pharmacokinetics;
Software;
Tissue Distribution
- From:
Acta Pharmaceutica Sinica
2014;49(1):16-22
- CountryChina
- Language:Chinese
-
Abstract:
Physiologically based pharmacokinetic model (PBPK), a mechanistic mathematic model, which can simulate the absorption, distribution, metabolism and excretion of drugs, is being more widely used in pharmaceutical research and development areas. This article reviews primarily the recent advances in the procedure of establishing a PBPK model, including specifying of the PBPK model structure, specification of the tissue model, writing of equations, set of model parameters, simulation and evaluation. Application significance, major challenges and future developments of PBPK model in pharmaceutical areas are also discussed.
