A new steroid with long cross-conjugation structure from the marine-derived fungus Aspergillus aculeatus.
- Author:
Yu WANG
;
Zhan-Lin LI
;
Tao LIU
;
Li TIAN
;
Yue-Hu PEI
;
Hui-Ming HUA
- Publication Type:Journal Article
- MeSH:
Animals;
Aspergillus;
chemistry;
Cell Line, Tumor;
drug effects;
Cholestenones;
chemistry;
isolation & purification;
pharmacology;
HL-60 Cells;
drug effects;
Humans;
Inhibitory Concentration 50;
Molecular Structure;
Seawater;
microbiology
- From:
Acta Pharmaceutica Sinica
2014;49(1):68-71
- CountryChina
- Language:English
-
Abstract:
A new steroid with a long cross-conjugation structure, 15a-hydroxy-(22E, 24R)-ergosta-3, 5, 8 (14), 22-tetraen-7-one (1), was isolated from the marine-derived fungus Aspergillus aculeatus. Its structure was established by the extensive spectroscopic analyses, and its cytotoxicities against P388, HL-60, and PC-3 cell lines were measured in vitro.
