Co-delivery of paclitaxel and cyclosporine by a novel liposome-silica hybrid nano-carrier for anti-tumor therapy via oral route.
- Author:
Li DENG
;
Ting-Ting SU
;
Xing-Liang HUANG
;
Ya-Hua WANG
;
Chong LI
- Publication Type:Journal Article
- MeSH:
ATP-Binding Cassette, Sub-Family B, Member 1;
antagonists & inhibitors;
Administration, Oral;
Animals;
Antineoplastic Agents, Phytogenic;
administration & dosage;
pharmacokinetics;
pharmacology;
Biological Availability;
Cyclosporine;
administration & dosage;
pharmacokinetics;
pharmacology;
Drug Carriers;
chemistry;
Female;
Liposomes;
chemistry;
Male;
Mice;
Nanoparticles;
Neoplasm Transplantation;
Paclitaxel;
administration & dosage;
pharmacokinetics;
pharmacology;
Particle Size;
Random Allocation;
Rats;
Rats, Sprague-Dawley;
Sarcoma 180;
pathology;
Silicon Dioxide;
chemistry;
Tumor Burden;
drug effects
- From:
Acta Pharmaceutica Sinica
2014;49(1):106-114
- CountryChina
- Language:Chinese
-
Abstract:
In this study, we developed a novel liposome-silica hybrid nano-carrier for tumor combination therapy via oral route, using paclitaxel and cyclosporine as a model drug pair. Optimization of the preparation of the drug-loading formulation and characterization of its physicochemical parameters and drug release profile were performed in vitro. Then in vivo pharmacodynamics and pharmacokinetics studies were performed. The results showed that the obtained formulation has a small particle size (mean diameter of 100.2 +/- 15.2 nm), a homogeneous distribution [the polydispersity index was (0.251 +/- 0.018)] and high encapsulation efficiency (90.15 +/- 2.47) % and (80.64 +/- 3.52) % for paclitaxel and cyclosporine respectively with a mild and easy preparation process. A sequential drug release trend of cyclosporine prior to palictaxel was observed. The liposome-silica hybrid nano-carrier showed good biocompatibility in vivo and co-delivery of cyclosporine and paclitaxel significantly enhanced the oral absorption of paclitaxel with improved anti-tumor efficacy, suggesting a promising approach for multi-drug therapy against tumor and other serious diseases via oral route.
