Association of FASL-844 polymorphism with the risk of idiopathic azoospermia and severe oligozoospermia.
- Author:
Wei WANG
1
;
Ning-xia LU
;
Yan-ai XIA
;
Xin-ru WANG
;
Wei ZHANG
;
Ning-hong SONG
;
Min WEI
;
Jian-tang SU
Author Information
- Publication Type:Journal Article
- MeSH: Adult; Azoospermia; genetics; Fas Ligand Protein; genetics; Genetic Predisposition to Disease; Genotype; Humans; Infertility, Male; genetics; Male; Middle Aged; Oligospermia; genetics; Polymerase Chain Reaction; Polymorphism, Restriction Fragment Length
- From: National Journal of Andrology 2007;13(4):302-305
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the distribution of FASL-844 polymorphism in southern Chinese males of Han nationality and examine the contribution of the polymorphism to susceptibility of idiopathic azoospermia and oligozoospermia.
METHODSFASL-844 polymorphism was genotyped by polymerase chain reaction and restriction fragment length polymorphism(PCR-RFLP) in 184 infertile patients with idiopathic azoospermia or severe oligozoospermia 236 normal fertile male controls.
RESULTSFrequencies of FASL-844 CT and TT genotypes of the patients were significantly different from those of the controls (P = 0.024; P = 0.008). Males with FASL-844 TT genotype had an increased risk of idiopathic azoospermia or severe oligozoospermia compared with those with CC genotype (OR 2.76, 95% CI: 1.20-6.35), and even a higher risk when compared with those with CC and CT genotypes (OR 2.90, 95% CI: 1.28-6.58).
CONCLUSIONFASL-844 polymorphism appears to be a genetic predisposing factor of idiopathic azoospermia or severe oligozoospermia among southern Chinese Han males.
