Hypoxia-inducible factor 1 and prostate cancer.
- Author:
Zhou-hui PAN
1
;
Zhao-dian CHEN
Author Information
1. Department of Urology, the Third Affiliated Hospital, Zhengzhou University, Zhengzhou, Henan 450052, China. doctorpzh@163.com
- Publication Type:Journal Article
- MeSH:
Humans;
Hypoxia-Inducible Factor 1;
physiology;
Male;
Prostatic Neoplasms;
diagnosis;
metabolism;
therapy
- From:
National Journal of Andrology
2007;13(4):356-359
- CountryChina
- Language:Chinese
-
Abstract:
Hypoxia-inducible factor 1 (HIF-1) has a close relation with prostate cancer. It is involved not only in angiogenesis, cell proliferation/survival and glucose metabolism but also in p53, p21 and signal transduction pathway in prostate cancer. Further studies of HIF-1 may yield new approaches to the diagnosis and treatment of prostate cancer. We present a review of the structure and biological functions of HIF-1 and its relation with prostate cancer.
