Relationship between HER-2/neu over-expression and androgen independent prostate cancer.
- Author:
Qiang BAI
1
;
Fang CHEN
;
Juan QI
;
Jian-hua CHEN
;
Yi-xin WANG
Author Information
- Publication Type:Journal Article
- MeSH: Androgens; physiology; Humans; Immunohistochemistry; Male; Neoplasm Staging; Neoplasms, Hormone-Dependent; metabolism; pathology; Prostatic Neoplasms; metabolism; pathology; Receptor, ErbB-2; biosynthesis
- From: National Journal of Andrology 2007;13(5):414-416
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect HER-2/neu expression in prostate cancer tissues of both androgen dependent and independent groups and to evaluate the role of HER-2/neu in androgen independent prostate cancer.
METHODSImmunohistochemical assay was used in the detection of HER-2/neu in the prostate cancer samples from 30 cases of androgen dependent cancer and 24 cases of androgen independent cancer. The correlation was analyzed between HER-2/neu over-expression and the tumor's clinical stage and Gleason score.
RESULTSThe rates of HER-2/neu over-expression were 10% and 33% in the androgen dependent group and the androgen independent group, significantly higher in the Gleason score >7 group and the clinical stage > T2 group than in the -7 group and the > T2 group (14.29% vs. 26.92%, 34.62% vs. 7.14%, P < 0.01).
CONCLUSIONThe rate of HER-2/neu over-expression is high in androgen independent prostate cancer and is correlated with the tumor stage and Gleason score.
