Effects of phytoestrogens on prostate cancer and benign prostatic hyperplasia.
- Author:
Yao FENG
1
;
Xin-yi XIA
;
Yu-feng HUANG
Author Information
1. PLA Research Institute of Clinical Laboratory Medicine, Nanjing General Hospital of Nanjing Command, PLA, Nanjing, 21002 Jiangsu, China.
- Publication Type:Journal Article
- MeSH:
Animals;
Disease Models, Animal;
Humans;
Male;
Phytoestrogens;
pharmacology;
Prostatic Hyperplasia;
pathology;
prevention & control;
Prostatic Neoplasms;
pathology;
prevention & control;
Rats;
Rats, Sprague-Dawley;
Rats, Wistar
- From:
National Journal of Andrology
2007;13(5):457-461
- CountryChina
- Language:Chinese
-
Abstract:
Phytoestrogens are non-steroidal estrogens widely distributed in many kinds of plants. They are natural compounds structurally similar to estrogen and with estrogenic or anti-androgenic activities. Prostate cancer (PCa) and benign prostatic hyperplasia (BPH) are androgen-dependent and associated with age. Recently, in many epidemiological and experimental researches, it has been reported that phytoestrogens play a role in the prevention and treatment of PCa and BPH. Regulation of sexual hormones, inhibition of cell proliferation, induction of cell apoptosis and anti-oxidation of such plant estrogens may be involved in the mechanisms.
