Aike mixture has good anti-inflammatory and analgesic effects on mice.
- Author:
Min-jian ZHANG
1
;
Ke-dan CHU
;
Xin-ling CHENG
;
Xu-dong PAN
;
Wan-jun CHENG
;
Kai-yuan YU
;
Yu-hong TAN
;
Jin-zhi LIU
;
Ya-lei SHI
;
Sheng ZHENG
;
Qiao-bin LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Chronic Disease; Disease Models, Animal; Drug Combinations; Male; Mice; Mice, Inbred ICR; Oleanolic Acid; analogs & derivatives; pharmacology; therapeutic use; Phytotherapy; Prostatitis; drug therapy; Saponins; pharmacology; therapeutic use
- From: National Journal of Andrology 2007;13(5):471-473
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the anti-inflammatory and analgesic actions of Aike Mixture (AKM).
METHODSA total of 100 male mice were randomly assigned into 5 groups: a normal control group, a drug control group (a hydrocortisone subgroup and an atropine subgroup), a high-dose AKM group, a mid-dose AKM group and a low-dose AKM group. Xylene was spread on the left ear of the experimental mice to induce inflammation, and 1% acetic acid solution injected into the abdominal cavity to produce pain so as to cause the body bend. Different doses of AKM were given and their actions observed.
RESULTSAKM had obvious anti-inflammatory effect on the xylene-induced ear tumefaction and inhibited the pain-caused body bend in the AKM groups, with significant difference from the normal control (P < 0.01).
CONCLUSIONAKM has good anti-inflammatory and analgesic effects, which is of clinical significance in the treatment of chronic prostatitis.
