Detection of DD3 mRNA in the urine of prostate cancer patients and its clinical significance.
- Author:
Guang-xiang LIU
1
;
Hong-qian GUO
;
Xiao-gong LI
;
Wei-dong GAN
;
Ling-qi ZENG
;
Hong-lei SHI
;
Shi-wei ZHANG
;
Tie-shi LIU
Author Information
- Publication Type:Journal Article
- MeSH: Aged; Aged, 80 and over; Antigens, Neoplasm; genetics; urine; Humans; Male; Middle Aged; Prostatic Neoplasms; diagnosis; RNA, Messenger; urine; Reverse Transcriptase Polymerase Chain Reaction; Sensitivity and Specificity
- From: National Journal of Andrology 2007;13(6):511-513
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo detect the differential display code 3 mRNA (DD3 mRNA) in the urine sample of patients with prostate cancer and to evaluate its clinical significance.
METHODSDD3 mRNA in the urine collected from 48 patients with prostate cancer, 23 patients with benign prostate hyperplasia (BPH) and 9 healthy male volunteers was measured by reverse transcriptase polymerase chain reaction (RT-PCR).
RESULTSDD3 products could not be detected in the urine samples of the BPH patients and healthy male volunteers, but could in 39/48 urine samples of the patients with prostate cancer. Significant difference was found between them (P < 0.01).
CONCLUSIONThe detection of DD3 mRNA in the urine promises to be a non-invasive, simple and sensitive method for the early diagnosis and post-treatment monitoring of prostate cancer.
