Effect of dimethoate on serum monoamines neurotransmitters in rats.
- Author:
Guo-Hong RUAN
1
;
Qiang-En WU
;
Ping GU
;
Li-Xing ZHENG
;
Xi-An GU
;
Zhi-Jun ZHOU
Author Information
- Publication Type:Journal Article
- MeSH: 3,4-Dihydroxyphenylacetic Acid; blood; Animals; Biogenic Monoamines; blood; Dimethoate; toxicity; Dopamine; blood; Dose-Response Relationship, Drug; Epinephrine; blood; Male; Norepinephrine; blood; Rats; Rats, Sprague-Dawley; Serotonin; blood
- From: Chinese Journal of Industrial Hygiene and Occupational Diseases 2006;24(11):645-648
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the effect of dimethoate on the monoamine Neurotransmitters, including norepinephrine (NE), epinephrine (E), serotonin (5-HT), dopamine (DA) and its metabolite (3, 4-hydroxyphenylacetic acid, DOPAC) in the serum of rats and furthermore to explore the non-cholinergic mechanism of organophosphate induced toxicity.
METHODSGroups of rats were treated with saline and 38.9, 83.7 and 180 mg/kg dimethoate respectively and were decapitated at the different time course from 0.5 to 24 hours after the administration. The monoamines neurotransmitters were determined by the reverse-phase high-performance liquid chromatography with the electrochemical detection.
RESULTSThe serum concentrations of DA (8.42% - 248.42% of the control), DOPAC (17.22% - 68.21% of the control) increased, according with the DM dosage and the exposure time, while the levels of NE (9.65% - 38.26% of the control) and E (11.00% - 32.62% of the control) contents decreased at the same time.
CONCLUSIONThese findings indicate that dimethoate induced toxic effects can alter the monoamine levels at the different dosage and the time exposure in the serum of rats. It suggests that some non-cholinergic mechanisms may be involved in the dimethoate intoxication.
