Biological function of Nogo-B.
- Author:
Wu-Jian XU
1
,
2
;
Guo-Qing SHEN
;
Qiang LI
Author Information
1. Department of Respiratory Disease, Changhai Hospital, Second Military Medical University, Shanghai 200433, China
2. China People's Liberation Army 73676, Wuxi 214162, China. E-mail: liqressh@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
Cell Membrane;
physiology;
Endoplasmic Reticulum;
physiology;
Humans;
Inflammation;
Myelin Proteins;
physiology;
Nogo Proteins
- From:
Acta Physiologica Sinica
2013;65(4):445-450
- CountryChina
- Language:Chinese
-
Abstract:
Nogo-B is a major family member of the reticulon protein family 4. It is widely expressed in the central nervous system and peripheral tissues, and is mainly located in endoplasmic reticulum and cell membrane. Previous studies have revealed that Nogo-B plays a key role in vascular injury, tissue repair and inflammation process. It also may be critical for apoptosis of tumor cells and central diseases. Further investigation of the molecular characteristics and biological function of Nogo-B might be of great help to understand its role in diverse diseases.
