Inhibitory effect of octreotide on the cross excitation of adjacent segment of spinal nerve in rat.
- Author:
Jun WANG
1
,
2
,
3
,
4
;
5
,
6
;
Dong-Yuan CAO
;
Yuan GUO
;
Shao-Jie MA
;
Yan ZHAO
Author Information
1. Department of Anatomy, Henan University College of Medicine, Kaifeng 475001, China
2. Department of Physiology and Pathophysiology, Xi'an Jiaotong University School of Medicine, Xi'an 710061, China
3. Department of Neural and Pain Sciences, University of Maryland School of Dentistry, Baltimore, Maryland 21201, USA. zhaoy502@mail.xjtu.edu.cn
4. Dongyuan_cao@hotmail.com.
5.
6. Dongyuan_cao@hotmail.com.
- Publication Type:Journal Article
- MeSH:
Animals;
Electric Stimulation;
Octreotide;
pharmacology;
Peptides, Cyclic;
pharmacology;
Rats;
Receptors, Somatostatin;
physiology;
Somatostatin;
analogs & derivatives;
Spinal Nerves;
drug effects
- From:
Acta Physiologica Sinica
2013;65(6):593-599
- CountryChina
- Language:Chinese
-
Abstract:
This study was to observe the effect and possible mechanism of somatostatin analogue octreotide (OCT) on cross excitation of adjacent segment of spinal nerve in rat. Cutaneous branches of T9-T13 spinal dorsal rami were chosen and dissected free for the following recording and stimulation. Only single unit fiber was used for recording, and the adjacent segment of nerve stem was used for antidromic electrical stimulation. To investigate the change of discharge rate and mechanical threshold, OCT and (or) somatostatin receptor antagonist cyclo-somatostatin (c-SOM) were applied to the receptive field following the antidromic electrical stimulation. The result showed that injection of OCT inhibited the increase of discharge rate and the decrease of mechanical threshold induced by the electrical stimulation (cross excitation); c-SOM reversed the effects of OCT. Application of c-SOM alone enhanced the cross excitation effects. The results suggest local application of somatostatin analogue OCT can inhibit the cross excitation between the two segments of spinal nerve by somatostatin receptor.
