TRPM2: a multifunctional ion channel for oxidative stress sensing.
- Author:
Xiaochen RU
1
;
Xiaoqiang YAO
Author Information
1. Shenzhen Research Institute and School of Biomedical Sciences, The Chinese University of Hong Kong, Hong Kong, China. ruxiaochen2013@gmail.com.
- Publication Type:Journal Article
- MeSH:
Adenosine Diphosphate Ribose;
metabolism;
Calcium;
physiology;
Calcium Channels;
physiology;
Humans;
Hydrogen Peroxide;
metabolism;
Oxidative Stress;
Reactive Oxygen Species;
metabolism;
TRPM Cation Channels;
physiology
- From:
Acta Physiologica Sinica
2014;66(1):7-15
- CountryChina
- Language:English
-
Abstract:
Transient receptor potential (TRP) superfamily is a superfamily of cation channels that can be divided into seven subfamilies. TRPM2 is the second member of the TRPM subfamily, which includes eight members, namely TRPM1-8. TRPM2 is widely expressed in excitable and non-excitable cells, where it forms a Ca(2+)-permeable cation channel and performs diverse cellular functions. TRPM2 channels are activated by ADP-ribose (ADPR), Ca(2+), H2O2 and other reactive oxygen species (ROS). It is established that TRPM2 serves as a cellular sensor for oxidative stress, mediating oxidative stress-induced [Ca(2+)]i increase and contributing to pathological processes in many cell types. Accumulating evidence has indicated that TRPM2 is a potential therapeutic target for oxidative stress-related diseases. This review will highlight recent progress in this field.
