Progress on Hedgehog signaling transduction.
- Author:
Ying TANG
1
,
2
;
Steven CHENG
Author Information
1. Central Laboratory, the First People's Hospital of Wujiang District, Suzhou 215200, China
2. Department of Developmental Genetics, Nanjing Medical University, Nanjing 210029, China. sycheng@njmu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Animals;
Cilia;
physiology;
Hedgehog Proteins;
physiology;
Receptors, G-Protein-Coupled;
physiology;
Signal Transduction;
Transcription Factors;
physiology
- From:
Acta Physiologica Sinica
2014;66(4):415-422
- CountryChina
- Language:Chinese
-
Abstract:
Hedgehog (Hh) signaling pathway plays an important role during embryonic development and pattern formation. Disruption of Hh pathway results in various developmental disorders and increasing cancer incidence. Here we provide a comprehensive review of the pathway members, focusing on how mammalian Hh regulates the Gli family of transcription factors through its downstream members, the so-called "canonical signaling pathway". Hh signaling pathway is highly conserved among species, and primary cilia plays an important role as a "signaling center" during vertebrate signal transduction. Further, in the past few years, numerous studies have shown that Hh signal can also be transduced through Gli-independent ways collectively referred to as "non-canonical signaling pathways", which can be subdivided into two modules: (i) those not requiring Smo and (ii) those downstream of Smo that do not require Gli transcription factors. Thus, we review the rapid progress on canonical and non-canonical Hh pathways.
