Correlation analysis of efficacy of yiqi chutan recipe in treating NSCLC and P4HB expression.

Author: Ling-ling SUN ; Li-zhu LIN ; Jing-xu ZHOU ; Zhuang-zhong CHEN ; Wen-hui TAO
Publication Type:Journal Article
MeSH: Carcinoma, Non-Small-Cell Lung; drug therapy; metabolism; Drugs, Chinese Herbal; therapeutic use; Humans; Lung; Lung Neoplasms; drug therapy; metabolism; Male; Procollagen-Proline Dioxygenase; metabolism; Protein Disulfide-Isomerases; metabolism
From: Chinese Journal of Integrated Traditional and Western Medicine 2015;35(2):184-187
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo study the predicting effect of proly 4-hydroxylase beta polypeptide (P4HB) in treating non-small cell lung cancer (NSCLC) patients by Yiqi Chutan Recipe (YCR).
METHODSTotally 46 stage III and IV NSCLC patients were treated by YCR for 4 therapeutic courses. Effect was assessed by RECIST of solid tumor. P4HB expression was detected in the lung cancer tissue by immunohistochemical assay. Factors affecting disease control rates (DCR) of YCR were analyzed by Logistic regression analysis. The correlation between P4HB expression and the effect of YCR was analyzed.
RESULTSThe DCR of advanced NSCLC treated by YCR was 36.96% (17/46 cases). P4HB was high expressed in advanced lung cancer tissue (6/15 cases). Gender, initial treatment, and retreatment are independent factors for affecting DCR of treating lung cancer by YCR.
CONCLUSIONP4HB might be taken as a factor for predicting the effect of YCR in treating NSCLC.