Relation between Chinese Medical Constitutions and Chemotherapy-induced Leucopenia in Breast Cancer Patients: a Clinical Study.
- Author:
Yi LIU
;
Qing-hua CHEN
;
Ye SUN
;
Yun CAI
;
Rui WANG
;
Ping-ping HAN
;
Zhe ZHANG
;
Rui WANG
;
Feng YE
- Publication Type:Journal Article
- MeSH: Breast Neoplasms; complications; drug therapy; Drugs, Chinese Herbal; therapeutic use; Female; Humans; Leukopenia; chemically induced; Medicine, Chinese Traditional; Yang Deficiency
- From: Chinese Journal of Integrated Traditional and Western Medicine 2015;35(6):664-667
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo analyze the relationship between Chinese medical constitutions and chemotherapy-induced leucopenia (CIL) of primary breast cancer patients.
METHODSTotally 306 breast cancer patients undergoing adjunctive chemotherapy for the 1st time, and effective 291 breast cancer patients were recruited in this study.Nine Basic Constitutional Scale was used before first chemotherapy. Chinese medical constitutions were classified and quantitatively scored. The highest grading for any item of adverse reactions in each case during the whole chemotherapy course was recorded after chemotherapy. Data were statistically analyzed using SPSS16.0.
RESULTSThere was no significant difference in CIL between different chemotherapy regimens and various Chinese medical constitutions of breast cancer patients (P > 0.05). Yang deficiency constitution is one risk factor for CIL. The higher the score of yang deficiency constitution, the more severe the CIL.
CONCLUSIONSYang deficiency constitution was correlated with the degree of CIL. The higher the score of yang deficiency constitution, the greater the risk of III-IV grade CIL in breast cancer patients.