Research advances in the protective effect of all-trans retinoic acid against podocyte injury.
- Author:
Xiu-Ping CHEN
1
;
Yuan-Han QIN
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. gxlb89121@163.com.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
drug effects;
Cell Differentiation;
drug effects;
Cell Proliferation;
drug effects;
Cytoprotection;
Humans;
Podocytes;
drug effects;
physiology;
Tretinoin;
pharmacology
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(6):719-723
- CountryChina
- Language:Chinese
-
Abstract:
All-trans retinoic acid (ATRA) is a vitamin A derivative and plays an important role in the regulation of cell aggregation, differentiation, apoptosis, proliferation, and inflammatory response. In recent years, some progress has been made in the role of ATRA in renal diseases, especially its protective effect on podocytes. This article reviews the research advances in podocyte injury, characteristics of ATRA, podocyte differentiation and regeneration induced by ATRA, and the protective effect of ATRA against proliferation, deposition of fibers, and apoptosis.
