Poor weight gain, recurrent metabolic alkalosis and hypokalemia in a neonate.
- Author:
Miao QIAN
1
;
Shu-Ping HAN
;
Zhang-Bing YU
;
Xiao-Hui CHEN
Author Information
1. Nanjing Maternity and Child Health Care Hospital Affiliated to Nanjing Medical University, Nanjing 210004, China. qianmiao1982@163.com.
- Publication Type:Case Reports
- MeSH:
Acidosis;
etiology;
Bartter Syndrome;
etiology;
therapy;
Female;
Humans;
Hypokalemia;
etiology;
Infant, Newborn;
Recurrence;
Weight Gain
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(7):812-815
- CountryChina
- Language:Chinese
-
Abstract:
The study reports a female neonate with a gestational age of 29weeks and a birth weight of 1 210 g. Ten minutes after birth, the neonate was admitted to the hospital due to shortness of breath. Several days after birth, the neonate presented with hyperglycemia, polyuria, and poor weight gain, accompanied by azotemia, hypochloremic metabolic alkalosis, hypokalemia, and hyponatremia. Laboratory examinations showed elevated levels of aldosterone, renin, and angiotensin II. Gene detection revealed SLC12A1 gene mutation. Neonatal Bartter syndrome was thus confirmed. The neonate was treated with sodium and potassium supplements, and was followed up for 8 months. During the follow-up, the mental and neural development of the neonate was almost normal at the corrected age, and regular reexaminations showed slight metabolic alkalosis and almost normal electrolyte levels. For the neonates who have the symptoms of unexplainable polyurine and electrolyte disorders, it is important to examine the levels of aldosterone, renin and angiotensin. A definite diagnosis of neonatal Bartter syndrome can be made based on the presence of SLC12A1 gene mutation.
