Research advances in immunological pathogenesis of immunoglobulin A vasculitis.
- Author:
Ya-Ting LIU
1
;
Si-Guang LU
Author Information
1. Department of Pediatrics, Lianyungang Hospital Affiliated to Xuzhou Medical University, Lianyungang, Jiangsu 222000, China. 978343990@qq.com.
- Publication Type:Journal Article
- MeSH:
Autoantibodies;
analysis;
Complement System Proteins;
physiology;
Cytokines;
physiology;
Glycosylation;
Humans;
Immunoglobulin A;
analysis;
Immunoglobulin E;
metabolism;
Vasculitis;
etiology;
immunology
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(7):837-840
- CountryChina
- Language:Chinese
-
Abstract:
Immunoglobulin A (IgA) vasculitis is the most common leukocytoclastic small-vessel vasculitis in children and mainly involves the small vessels in the skin, joints, digestive tract, and kidneys. Its pathogenesis is still unclear. Currently, it is believed that environmental factors can cause autoimmune dysfunction and lead to the deposition of IgA-containing immune complexes on the wall of arterioles on the basis of genetic factors. This article reviews the research advances in the role of immune factors in the pathogenesis of IgA vasculitis.
