Association between BIM gene and glucocorticoid resistance in children with acute lymphoblastic leukemia.
- Author:
Jin-Yun XU
1
;
Jian-Ming LUO
Author Information
1. Department of Pediatrics, First Affiliated Hospital of Guangxi Medical University, Nanning 530021, China. jmluo@aliyun.com.
- Publication Type:Journal Article
- MeSH:
Apoptosis;
Bcl-2-Like Protein 11;
genetics;
Child;
Drug Resistance;
Glucocorticoids;
therapeutic use;
Humans;
Precursor Cell Lymphoblastic Leukemia-Lymphoma;
drug therapy;
genetics;
pathology
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(8):945-949
- CountryChina
- Language:Chinese
-
Abstract:
Acute lymphoblastic leukemia (ALL) is the most common malignant hematological disease in childhood. Glucocorticoids are frequently used in the chemoradiotherapy regimen for ALL and can induce the apoptosis of ALL cells through several signaling pathways, but about 10% of ALL children have poor response to glucocorticoids. Studies have revealed that glucocorticoids induce the apoptosis of ALL cells by upregulating the expression of BIM gene, and BIM gene is associated with glucocorticoid resistance in childhood ALL. This article reviews the recent studies on glucocorticoid resistance in childhood ALL, especially the role of BIM and its expression products in this process.
