Advances in genetic research of cerebral palsy.
- Author:
Fang-Fang WANG
1
;
Rong LUO
;
Yi QU
;
De-Zhi MU
Author Information
1. Department of Pediatrics, West China Second University Hospital, Sichuan University, Chengdu 610041, China. lrscu@scu.edu.cn.
- Publication Type:Journal Article
- MeSH:
Cerebral Palsy;
etiology;
genetics;
Chromosome Aberrations;
Cytokines;
genetics;
DNA Copy Number Variations;
Genetic Predisposition to Disease;
Genome-Wide Association Study;
Humans;
Mutation
- From:
Chinese Journal of Contemporary Pediatrics
2017;19(9):1022-1026
- CountryChina
- Language:Chinese
-
Abstract:
Cerebral palsy is a group of syndromes caused by non-progressive brain injury in the fetus or infant and can cause disabilities in childhood. Etiology of cerebral palsy has always been a hot topic for clinical scientists. More and more studies have shown that genetic factors are closely associated with the development of cerebral palsy. With the development and application of various molecular and biological techniques such as chromosome microarray analysis, genome-wide association study, and whole exome sequencing, new achievements have been made in the genetic research of cerebral palsy. Chromosome abnormalities, copy number variations, susceptibility genes, and single gene mutation associated with the development of cerebral palsy have been identified, which provides new opportunities for the research on the pathogenesis of cerebral palsy. This article reviews the advances in the genetic research on cerebral palsy in recent years.
