Expressions of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids.
- Author:
Yi SUN
1
;
Jian-xing SONG
;
Zi-min WANG
;
Jiang-ping CHEN
;
Ying CHEN
;
Xiao-jie TAN
;
Jin BAI
Author Information
- Publication Type:Journal Article
- MeSH: Adolescent; Adult; Female; Humans; Keloid; metabolism; Male; Middle Aged; Protein-Serine-Threonine Kinases; metabolism; Receptors, Transforming Growth Factor beta; metabolism; Smad2 Protein; metabolism; Smad3 Protein; metabolism; Smad7 Protein; metabolism; Young Adult
- From: Chinese Journal of Plastic Surgery 2006;22(5):368-370
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo investigate the expression of TGF-betaR I, Smad2, Smad3 and Smad7 in keloids, normal scars and normal skins. Discuss the significance of these proteins in the course of keloid.
METHODSImmunohistochemistry method was used to detect the expression intensity and distribution of these proteins in above 3 kinds of different tissues in 44 cases. Statistics was used to analyze the data.
RESULTSThe expression of TGF-betaR I were much stronger in keloid than in the other two tissues. The expression of Smad7 were lower in keloids. The increase expression of Smad2,3 were not obvious, but they were found to accumulate in the nucleus.
CONCLUSIONSThe results indicate that over-expression of TGF-betaR I, low-expression of Smad7 and accumulation of Smad2,3 may be one of the etiological factors of keloids. This research may provide a new idea to prevent and treat keloids or other fibrosis diseases in the future.
