Activity changes of protein kinase C in effect of interferon-gamma on wound healing and cicatrisation.
- Author:
Xuan-fen ZHANG
1
;
Shu-zhong GUO
;
Lin-xi ZHANG
;
Kai LIU
Author Information
- Publication Type:Journal Article
- MeSH: Animals; Cicatrix; metabolism; Female; Interferon-gamma; pharmacology; Male; Protein Kinase C; drug effects; metabolism; Rabbits; Signal Transduction; Skin; injuries; Wound Healing; drug effects
- From: Chinese Journal of Plastic Surgery 2006;22(6):442-444
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo study the roles of protein kinase C (PKC) in effect of interferon-gamma (IFN-gamma) on wound healing and cicatrization.
METHODSIFN-gamma was applied on the wound and into the scar tissues of rabbit ear before or after wound healing. PKC activities in the tissues from 0, 3, 6 d, 11-16 d post-wounding and from 14, 30 and 45d post-epithelization were measured by phosphorus (32p) incorporation. The time of wound epithelization and scar changes were also observed.
RESULTSThe PKC activity in granulation tissue, wound margin tissue and scar tissue elevated obviously in comparing with that of normal skin (P < 0.01). IFN-gamma did not change PKC activity (P > 0.05). But it delayed the wound healing (P < 0.01) and inhibited scar hyperplasia (P <0.05).
CONCLUSIONSPKC might not mediate the signal of IFN-gamma inhibiting the wound healing and scar hyperplasia. But PKC might be related to the wound healing and scar hyperplasia.
