Discoidin domain receptors (DDRs) expression in pathological scar fibroblast formation.
- Author:
Yu-Zhi JIANG
1
;
Xin XING
;
Jun-Hui WEN
;
Chun-Yu XUE
;
Jing-De ZHANG
;
Ming-li ZHANG
Author Information
- Publication Type:Journal Article
- MeSH: Cell Proliferation; Cells, Cultured; Cicatrix; metabolism; pathology; Discoidin Domain Receptors; Female; Fibroblasts; metabolism; Humans; Male; Receptor Protein-Tyrosine Kinases; metabolism; Receptors, Mitogen; metabolism
- From: Chinese Journal of Plastic Surgery 2007;23(2):134-136
- CountryChina
- Language:Chinese
-
Abstract:
OBJECTIVETo explore the role of discoidin domain receptors (DDRs) in the formation of the keloid.
METHODSThe real-time quantitative PCR was used to compare the DDRs expression in the keloids and normal fibroblasts.
RESULTSThe level of DDR1 expression was significantly higher in keloid than in normal fibroblast (20.98 vs 4.2, P <0.01; 7.9 vs 4.23, P <0.05). The level of DDR1 expression in keloid was also higher significantly than that in hypertropic scar (20.98 vs 7.9, P < 0.01). However, the level of DDR2 expression was somewhat higher in keloid than in normal fibroblasts, the difference seemed not to be significantly in probability (358, 332 vs 278, P > 0.05).
CONCLUSIONSDDRs may exert effect on keloid cell behaviours.
