Preparation and properties of novel human-like collagen-silk fibroin scaffold for blood vessel.
- Author:
Chenhui ZHU
1
;
Daidi FAN
;
Xiaoxuan MA
;
Wenjiao XUE
;
Junfeng HUI
;
Lan CHEN
;
Zhiguang DUAN
;
Pu MA
Author Information
1. Shaanxi Key Laboratory of Degradable Biomedical Materials, Northwest University, Xi'an 710069, China.
- Publication Type:Journal Article
- MeSH:
Biocompatible Materials;
chemistry;
Biomechanical Phenomena;
Blood Vessels;
physiology;
Collagen;
chemistry;
Fibroins;
chemistry;
Humans;
Materials Testing;
Porosity;
Tissue Engineering;
methods;
Tissue Scaffolds
- From:
Chinese Journal of Biotechnology
2009;25(8):1225-1233
- CountryChina
- Language:Chinese
-
Abstract:
In order to improve tensile property of vascular scaffold, we blended silk fibroin with novel human-like collagen with the mass ratio of 9:1, 7:3 and 5:5 (W/W), and then fabricated blood vessel tubular graft by freeze-drying process. We studied microstructure, mechanical properties, elements composites, degradability and biocompatibility of vascular scaffolds. These results showed that tubular scaffold with mass ratio 7:3 exhibited interconnected porous structure with pore size at (60 +/- 5) microm and porosity of 85%; achieved the desirable mechanical property (strain of 50% +/- 5% and stress of 332 +/- 16 kPa); had relatively slow degradation rate; could enhance cell adhesion and proliferation and had superior biocompatibility.
