Characteristics of mutation on rpoB gene of rifampicin-resistant tuberculosis strains insolated in Ha Noi and Ho Chi Minh City
- Author:
Anh Duc Dang
- Publication Type:Journal Article
- Keywords:
tuberculosis
- MeSH:
Tuberculosis;
Mutation;
Rifampin
- From:Journal of Practical Medicine
2002;435(11):19-20
- CountryViet Nam
- Language:Vietnamese
-
Abstract:
57 rifampicin-resistant tuberculosis strains isolated from Ha Noi Institute of Tuberculosis and Lung Diseases and Pham Ngoc Thach Tuberculosis Center of Ho Chi Minh City were involved in this study. The regimen included 2-month SHRZ and 4-month HR. All of these strains were resistant to rifampicin. It was found that rifampicin-resistant tuberculosis strains had mutations on rpoB gene. The mutation frequency of tuberculosis trains isolated from Ha Noi and Ho Chi Minh City was highest on 526 locus (55% and 41.6%, respectively) and 531 locus (30% and 33%, respectively).
