Survival analysis of AIDS patients of 15 years or above years old after initiation antiretroviral treatment in Henan province during 2005 to 2014.

Wenjie Yang; Panying Fan; Yan Liang; Yugang Nie; Ning LI; Dingyong Sun; Qian Zhu; Zhe Wang; Email: Wangzhe@hncdccomcn

Return

Survival analysis of AIDS patients of 15 years or above years old after initiation antiretroviral treatment in Henan province during 2005 to 2014.

Author: Wenjie YANG ¹ ; Panying FAN ¹ ; Yan LIANG ¹ ; Yugang NIE ¹ ; Ning LI ¹ ; Dingyong SUN ¹ ; Qian ZHU ¹ ; Zhe WANG ² ; Email: WANGZHE@HNCDC.COM.CN.
Author Information

1. Institute for AIDS/STD Prevention and Cure, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China.
2. Institute for AIDS/STD Prevention and Cure, Henan Provincial Center for Disease Control and Prevention, Zhengzhou 450016, China
Publication Type:Journal Article
MeSH: Acquired Immunodeficiency Syndrome; drug therapy; epidemiology; Anti-Retroviral Agents; therapeutic use; China; epidemiology; Drug Therapy, Combination; Female; Humans; Lymphocyte Count; Male; Nevirapine; therapeutic use; Proportional Hazards Models; Retrospective Studies; Risk Factors; Stavudine; therapeutic use; Survival Analysis; Survival Rate; Zidovudine; therapeutic use
From: Chinese Journal of Preventive Medicine 2015;49(12):1061-1066
CountryChina
Language:Chinese
Abstract:
OBJECTIVETo investigate the survival rate of AIDS patients after receiving antiretroviral therapy(ART) in Henan province and to determine factors associated with survival status.
METHODSDatabase of AIDS patients receiving ART were downloaded from China Information System for Disease Preventioin and Control-AIDS, retrospective study method was conducted to analyze the information.
INCLUSION CRITERIAinitially received national free ART during January, 2005 to December, 2014; aged 15 years or above; and with relatively complete baseline information and follow-up information. The accumulated survival rate of AIDS patients was calculated by life table method and the influencing factors were analyzed by Cox proportional hazard model.
RESULTSTotal 30 376 AIDS patients were enrolled in this study. During the follow-up period, a total of 3 927 cases died from HIV/AIDS related diseases. The mortality of all patients was 3.2/100 person year. After 1, 5, 10 years after the initiation of ART, the rates of accumulate survival rate were 93.7%, 85.3%, and 78.4%, respectively. Stepwise regression was used to conduct the time multiple factors analysis, the results showed that man (HR=1.28, 95%CI: 1.20-1.37), older age (HR=1.20, 95% CI: 1.16-1.24), others marital status except marrage or cohabitation (HR=1.20,95% CI: 1.12-1.29), more number of symptoms (HR=1.11, 95%CI: 1.07-1.14), initial treatment were main stavudine (D4T) or zidovudine (AZT)+ didanosine(DDI)+ nevirapine (NVP) or efevirenz (EFV) (HR=1.12, 95% CI: 1.04-1.20), missing drug in the past 7 days (HR=18.36,95%CI: 17.08-19.74) among AIDS patients had high mortality risk, homosexuality sexual transmission (HR=0.59, 95% CI: 0.40-0.87), higher baseline count of CD4(+)T lymphocyte (relative to 0-200 cells/µl group, HR (95%CI) were 0.57 (0.53-0.62), 0.43(0.37-0.49), 0.33 (0.27-0.40) in 201-350 cells/µl group, 351-500 cells/µl group, and ≥501 cells/µl group, respectively), higher educations (HR=0.89, 95% CI: 0.83-0.95) had low mortality risk.
CONCLUSIONSurvival rate was higher after initial antiretroviral treatment among AIDS patients in Henan province. AIDS patient will have shorter survival time after antiviral treatment under one or more following conditions: higher age, male, initial treatment with D4T or AZT + DDI + NVP or EFV, lower baseline CD4 (+) T lymphocyte count, ever missed antiviral drugs in past 7 days of latest follow-up.