C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China.

Yun Fan Tian; Yi Peng Zhou; Chong Ke Zhong; Batu Buren; Tian XU; Hong Mei LI; Ming Zhi Zhang; Ai Li Wang; Yong Hong Zhang

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C-reactive Protein Level, Apolipoprotein B-to-apolipoprotein A-1 Ratio, and Risks of Ischemic Stroke and Coronary Heart Disease among Inner Mongolians in China.

Author: Yun Fan TIAN ¹ ; Yi Peng ZHOU ¹ ; Chong Ke ZHONG ¹ ; Batu BUREN ² ; Tian XU ³ ; Hong Mei LI ¹ ; Ming Zhi ZHANG ¹ ; Ai Li WANG ¹ ; Yong Hong ZHANG ¹
Author Information

1. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China.
2. Department of Epidemiology, Tongliao Center for Disease Prevention and Control, Tongliao 028005, Inner Mongolia, China.
3. Department of Epidemiology, School of Public Health and Jiangsu Key Laboratory of Preventive and Translational Medicine for Geriatric Diseases, Medical College of Soochow University, Suzhou 215123, Jiangsu, China
Publication Type:Journal Article
Keywords: Apolipoprotein B-to-apolipoprotein A-1 ratio; C-reactive protein; Coronary heart disease; Ischemic stroke
MeSH: Adult; Apolipoproteins A; classification; genetics; metabolism; Apolipoproteins B; genetics; metabolism; C-Reactive Protein; genetics; metabolism; Cohort Studies; Coronary Disease; epidemiology; etiology; Gene Expression Regulation; Humans; Mongolia; epidemiology; Prospective Studies; Risk Factors; Stroke; epidemiology; etiology; Young Adult
From: Biomedical and Environmental Sciences 2016;29(7):467-474
CountryChina
Language:English
Abstract:
OBJECTIVEWe aimed to investigate the cumulative effect of high CRP level and apolipoprotein B-to-apolipoprotein A-1 (ApoB/ApoA-1) ratio on the incidence of ischemic stroke (IS) or coronary heart disease (CHD) in a Mongolian population in China.
METHODSFrom June 2003 to July 2012, 2589 Mongolian participants were followed up for IS and CHD events based on baseline investigation. All the participants were divided into four subgroups according to C-reactive protein (CRP) level and ApoB/ApoA-1 ratio. Cox proportional hazard models were used to estimate the hazard ratios (HRs) and 95% confidence intervals (CIs) for the IS and CHD events in all the subgroups.
RESULTSThe HRs (95% CI) for IS and CHD were 1.33 (0.84-2.12), 1.14 (0.69-1.88), and 1.91 (1.17-3.11) in the 'low CRP level with high ApoB/ApoA-1', 'high CRP level with low ApoB/ApoA-1', and 'high CRP level with high ApoB/ApoA-1' subgroups, respectively, in comparison with the 'low CRP level with low ApoB/ApoA-1' subgroup. The risks of IS and CHD events was highest in the 'high CRP level with high ApoB/ApoA-1' subgroup, with statistical significance.
CONCLUSIONHigh CRP level with high ApoB/ApoA-1 ratio was associated with the highest risks of IS and CHD in the Mongolian population. This study suggests that the combination of high CRP and ApoB/ApoA-1 ratio may improve the assessment of future risk of developing IS and CHD in the general population.