Association of the ADIPOQ Rs2241766 and Rs266729 Polymorphisms with Metabolic Syndrome in the Chinese Population: A Meta-analysis.
- Author:
Jun Mei ZHOU
1
;
Ming ZHANG
1
;
Shu WANG
2
;
Bing Yuan WANG
3
;
Cheng Yi HAN
3
;
Yong Cheng REN
3
;
Lu ZHANG
3
;
Hong Yan ZHANG
3
;
Xiang Yu YANG
3
;
Yang ZHAO
3
;
Dong Sheng HU
1
Author Information
- Publication Type:Journal Article
- Keywords: ADIPOQ; Meta-analysis; Metabolic syndrome; Polymorphisms
- MeSH: Adiponectin; genetics; metabolism; China; epidemiology; Genetic Predisposition to Disease; Genotype; Humans; Metabolic Syndrome; epidemiology; genetics; Polymorphism, Genetic; Risk Factors
- From: Biomedical and Environmental Sciences 2016;29(7):505-515
- CountryChina
- Language:English
-
Abstract:
OBJECTIVEThis meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome (MS) in the Chinese population.
METHODSWe searched for articles in MEDLINE via PubMed, EMBASE, HuGE Navigator, CNKI, and Wanfang databases and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to determine the strength of associations in fixed- or random-effects models.
RESULTSWe included 21 articles in the meta-analysis: 17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 controls. We found an increased risk of MS with the ADIPOQ rs2241766 polymorphism in some genetic models (allele model: OR=1.12, 95% CI: 1.03-1.21; dominant model: OR=1.15, 95% CI: 1.04-1.28; homozygote model: OR=1.22, 95% CI: 1.00-1.49) but no association with the ADIPOQ rs266729 polymorphism (allele model: OR=0.98, 95% CI: 0.82-1.17; dominant model: OR=0.90, 95% CI: 0.79-1.02; recessive model: OR=1.09, 95% CI: 0.85-1.39; homozygote model: OR=1.03, 95% CI: 0.80-1.33).
CONCLUSIONThe results of this meta-analysis suggest an association between the ADIPOQ rs2241766 polymorphism and MS in the Chinese population. G allele of ADIPOQ rs2241766 increases the risk of MS. Better designed studies with different ethnic populations and larger sample sizes are needed for assessing the relationship between ADIPOQ rs2241766 and rs266729 polymorphisms and MS in the future.
