Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population.

Mohammad NADERI; Mohammad HASHEMI; Gholamreza BAHARI

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Lack of Association between rs4331426 Polymorphism in the Chr18q11.2 Locus and Pulmonary Tuberculosis in an Iranian Population.

Author: Mohammad NADERI ¹ ; Mohammad HASHEMI ² ; Gholamreza BAHARI ³
Author Information

1. Infectious Diseases and Tropical Medicine Research Center, Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
2. Cellular and Molecular Research Center,Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran
3. Cellular and Molecular Research Center,Zahedan University of Medical Sciences, Zahedan 98167-43181, Iran.
Publication Type:Journal Article
Keywords: Polymorphism; Tuberculosis; rs4331426
MeSH: Adult; Aged; Case-Control Studies; Chromosomes, Human, Pair 18; genetics; Female; Genetic Predisposition to Disease; Humans; Iran; epidemiology; Male; Middle Aged; Polymorphism, Genetic; Tuberculosis, Pulmonary; epidemiology; genetics
From: Biomedical and Environmental Sciences 2016;29(7):516-520
CountryChina
Language:English
Abstract:
OBJECTIVEThe effect of rs4331426 polymorphism in the Chr18q11.2 locus on pulmonary tuberculosis (PTB) risk was evaluated.
METHODSThis case-control study included 208 PTB patients and 204 healthy subjects. Genotyping of the rs4331426 variant was conducted using polymerase chain reaction restriction fragment length polymorphism.
RESULTSThe frequencies of genotypes AA, AG, and GG polymorphisms were 83.1%, 15.9%, and 1.0% in the PTB group and 84.3%, 15.2%, and 0.5% in the control group, respectively. The frequency of the minor (G) allele was 8.9% in the PTB group and 8.1% in controls. Neither genotype nor allele frequencies of the rs4331426 variant showed statistically significant differences between PTB and controls. In addition, stratification by sex showed no significant association between the rs4331426 variant and PTB risk in males or females.
CONCLUSIONIn conclusion, the results of this study do not support an association between the rs4331426 polymorphism and risk of PTB in an Iranian population.