8-isoprostane as Oxidative Stress Marker in Coal Mine Workers.
- Author:
Zlatko ZIMET
1
;
Marjan BILBAN
2
;
Mateja Marc MALOVRH
3
;
Peter KOROŠEC
3
;
Borut POLJŠAK
4
;
Joško OSREDKAR
5
;
Mira ŠILAR
3
Author Information
1. National Institute of Public Health, Trubarjeva 2, 1000 Ljubljana, Slovenia.
2. Department of Public Health, Faculty of Medicine, University of Ljubljana, Zaloška 4, 1000 Ljubljana Slovenia.
3. University Clinic of Pulmonary and Allergic Diseases Golnik, Golnik 36, 4204 Golnik, Slovenia.
4. Faculty of Health Sciences, University of Ljubljana, Zdravstvena pot 5, 1000 Ljubljana, Slovenia.
5. University Medical Centre Ljubljana, Institute of Clinical Chemistry and Biochemistry, Njegoseva 4, 1000 Ljubljana, Slovenia.
- Publication Type:Journal Article
- MeSH:
Adult;
Biomarkers;
analysis;
Breath Tests;
Coal;
adverse effects;
Coal Mining;
manpower;
Dinoprost;
analogs & derivatives;
analysis;
Dust;
analysis;
Humans;
Male;
Middle Aged;
Miners;
statistics & numerical data;
Occupational Exposure;
analysis;
Oxidative Stress
- From:
Biomedical and Environmental Sciences
2016;29(8):589-593
- CountryChina
- Language:English
-
Abstract:
This study was to investigate whether working in conditions of elevated concentrations of mine gases (CO2, CO, CH4, DMS) and dust may result in oxidative stress. Coal miners (n=94) from the Velenje Coal mine who were arranged into control group and three groups according to a number of consecutive working days. 8-isoprostane as a biological marker of oxidative stress was measured in exhaled breath condensate (EBC). Miners who worked for three consecutive days had higher 8-isoprostane values in EBC compared to the control group. Gas/dust concentrations and exposure time of a single/two day shift seem too low to trigger immediate oxidative stress.
