Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants.

Po Wang; Rui DU; Lin Lin; Lin Ding; Kui Peng; Yu XU; Min XU; Yu Fang BI; Wei Qing Wang; Guang Ning; Jie Li LU

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Association between Free Triiodothyronine Levels and Peripheral Arterial Disease in Euthyroid Participants.

Author: Po WANG ^{1
,

2} ; Rui DU ¹ ; Lin LIN ¹ ; Lin DING ¹ ; Kui PENG ¹ ; Yu XU ¹ ; Min XU ¹ ; Yu Fang BI ¹ ; Wei Qing WANG ¹ ; Guang NING ¹ ; Jie Li LU ¹ ;
Author Information

1. National Clinical Research Center for Metabolic Diseases, Shanghai Clinical Center for Endocrine and Metabolic Diseases, Department of Endocrinology, Rui-Jin Hospital, Shanghai Jiao-Tong University School of Medicine, Shanghai 200025, China
2. Shanghai Institute of Endocrine and Metabolic Diseases, Shanghai 200025, China.
Publication Type:Journal Article
MeSH: Aged; Aged, 80 and over; Cross-Sectional Studies; Female; Humans; Male; Middle Aged; Odds Ratio; Peripheral Arterial Disease; blood; Risk Factors; Thyroxine; blood; Triiodothyronine; blood
From: Biomedical and Environmental Sciences 2017;30(2):128-133
CountryChina
Language:English
Abstract: This current cross-sectional study investigates the relationship between thyroid hormones and peripheral artery disease (PAD) among euthyroid Chinese population aged 40 years and above. Serum free triiodothyronine (FT3), free thyroxin (FT4), thyroid-stimulating hormone (TSH), and thyroid antibodies were measured. PAD was defined as ankle-brachial index (ABI) < 0.9. There were 91 (2.9%) PAD cases among the 3,148 euthyroid study participants. Participants in the highest quartile of FT3 and free-triiodothyronine-to-free-thyroxin (FT3/FT4 ratio) had a decreased risk of prevalent PAD (multivariate-adjusted odds ratio, 95% confidence interval: 0.32, 0.15-0.62, P for trend = 0.01 and 0.31, 0.13-0.66, P for trend = 0.004, respectively) compared to those in the lowest quartile. To conclude, FT3 levels and the FT3/FT4 ratio was inversely associated with prevalent PAD in euthyroid Chinese population aged 40 years and above.