Effects of Selenium on Fusarium Growth and Associated Fermentation Products and the Relationship with Chondrocyte Viability.

Hong Yin; Yan Zhang; Feng Zhang; Jin Tao HU; Yu Meng Zhao; Bo Lun Cheng

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Effects of Selenium on Fusarium Growth and Associated Fermentation Products and the Relationship with Chondrocyte Viability.

Author: Hong YIN ^{1
,

2} ; Yan ZHANG ¹ ; Feng ZHANG ¹ ; Jin Tao HU ³ ; Yu Meng ZHAO ³ ; Bo Lun CHENG ³
Author Information

1. The College of Life Science, Northwest University, Xi'an 710069, Shaanxi, China
2. Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, Xi'an 710069, Shaanxi, China.
3. The College of Life Science, Northwest University, Xi'an 710069, Shaanxi, China.
Publication Type:Journal Article
MeSH: Animals; Cell Survival; Cells, Cultured; Chondrocytes; pathology; Fermentation; Fusarium; drug effects; physiology; Rabbits; Selenium; pharmacology
From: Biomedical and Environmental Sciences 2017;30(2):134-138
CountryChina
Language:English
Abstract: This study determined the effects of selenium on the growth of Fusarium strains and the effects of products extracted from the fungal cultures on relevant indicators of chondrocytes injury. The results showed that selenium supplementation resulted in differential effects on the mycelial growth of the strains. Levels of the chondrocyte injury indicators, including cell viability, proteoglycan and type II collagen contents and their mRNA expressions, were all reduced to varying degrees when the chondrocytes were incubated with fermentation extracts, the inhibitory effect varied depending on selenium content supplemented to fungal culture media. The results indicated that certain chain relations existed between the content of selenium in the environment, the production of some metabolites by fungi, and the occurrence of chondrocyte damage. The extent of this relationship and the role it plays in Kaschin-Beck disease pathogenesis merit further study.