The Effect of PCDH15 Gene Variations on the Risk of Noise-induced Hearing Loss in a Chinese Population.
- Author:
Xiang Rong XU
1
;
Jing Jing WANG
1
;
Qiu Yue YANG
2
;
Jie JIAO
3
;
Li Hua HE
1
;
Shan Fa YU
3
;
Gui Zhen GU
3
;
Guo Shun CHEN
4
;
Wen Hui ZHOU
3
;
Hui WU
3
;
Yan Hong LI
3
;
Huan Ling ZHANG
4
;
Zeng Rui ZHANG
3
;
Xian Ning JIN
1
Author Information
- Publication Type:Journal Article
- MeSH: Cadherins; genetics; China; Genetic Predisposition to Disease; Genetic Variation; Hearing Loss, Noise-Induced; epidemiology; genetics; Humans; Risk Factors
- From: Biomedical and Environmental Sciences 2017;30(2):143-146
- CountryChina
- Language:English
- Abstract: Noise-induced hearing loss (NIHL) is a complex disease caused by interactions between environmental and genetic factors. This study investigated whether genetic variability in protocadherin related 15 (PCDH15) underlies an increased susceptibility to the development of NIHL in a Chinese population. The results showed that compared with the TT genotype of rs11004085, CT/CC genotypes were associated with an increased risk of NIHL [adjusted odds ratio (OR) = 2.64; 95% confidence interval (CI): 1.14-6.11, P = 0.024]. Additionally, significant interactions between the rs11004085 and rs978842 genetic variations and noise exposure were observed in the high-level exposure groups (P < 0.05). Furthermore, the risk haplotype TAGCC was observed when combined with higher levels of noise exposure (P < 0.05). Thus, our study confirms that genetic variations in PCDH15 modify the susceptibility to NIHL development in humans.
