Renal Tubular Acidosis in Patients with Primary Sjögren's Syndrome.
- Author:
Su Woong JUNG
1
;
Eun Ji PARK
;
Jin Sug KIM
;
Tae Won LEE
;
Chun Gyoo IHM
;
Sang Ho LEE
;
Ju Young MOON
;
Yang Gyun KIM
;
Kyung Hwan JEONG
Author Information
- Publication Type:Case Report
- Keywords: Sjögren's syndrome; Osteomalacia; Renal tubular acidosis; Hypokalemia
- MeSH: Acid-Base Equilibrium; Acidosis; Acidosis, Renal Tubular*; Autoantibodies; Diagnosis; Exocrine Glands; Fanconi Syndrome; Female; Femoral Fractures; Glomerulonephritis; Humans; Hypokalemia; Kidney; Muscle Weakness; Nephritis, Interstitial; Osteomalacia; Paralysis; Saliva; Tears
- From:Electrolytes & Blood Pressure 2017;15(1):17-22
- CountryRepublic of Korea
- Language:English
- Abstract: Primary Sjögren's syndrome (pSS) is characterized by lymphocytic infiltration of the exocrine glands resulting in decreased saliva and tear production. It uncommonly involves the kidneys in various forms, including tubulointerstitial nephritis, renal tubular acidosis, Fanconi syndrome, and rarely glomerulonephritis. Its clinical symptoms include muscle weakness, periodic paralysis, and bone pain due to metabolic acidosis and electrolyte imbalance. Herein, we describe the cases of two women with pSS whose presenting symptoms involve the kidneys. They had hypokalemia and normal anion gap metabolic acidosis due to distal renal tubular acidosis and positive anti-SS-A and anti-SS-B autoantibodies. Since one of them experienced femoral fracture due to osteomalacia secondary to renal tubular acidosis, an earlier diagnosis of pSS is important in preventing serious complications.
