Central Diabetes Insipidus Linked to Rathke's Cleft Cyst, Polyuria in a 17-year-old Girl.
- Author:
Ha Yeon KIM
1
;
Seung Jin LEE
;
Eun Hui BAE
;
Seong Kwon MA
;
Soo Wan KIM
Author Information
- Publication Type:Case Report
- Keywords: Central diabetes insipidus; Rathke's cleft cyst; Polyuria
- MeSH: Adolescent*; Deamino Arginine Vasopressin; Diabetes Insipidus, Neurogenic*; Diagnosis, Differential; Female*; Humans; Hypopituitarism; Magnetic Resonance Imaging; Occupations; Osmolar Concentration; Pituitary Gland; Plasma; Polydipsia; Polyuria*; Vasopressins
- From:Electrolytes & Blood Pressure 2017;15(1):23-25
- CountryRepublic of Korea
- Language:English
- Abstract: A 17-year-old girl presented with polyuria (7 L/day) and polydipsia for one year. Initial urine osmolality was 113mOsm/kg H₂O. Following 6 h of fluid restriction, serum plasma osmolality reached 300mOsm/kg H₂O, whereas urine osmolality was 108mOsm/kg H₂O. Urine osmolality was increased by 427% from 108 to 557mOsm/kg after vasopressin challenge. The patient was diagnosed with central diabetes insipidus, possibly derived from the atypical occupation of a Rathke's cleft cyst at the pituitary stalk following magnetic resonance imaging with enhancement. She was discharged with desmopressin nasal spray (10 µg); urine output was maintained at 2-3 L/day, and urine osmolality was >300 mOsm/kg. Additional pituitary image studies and evaluation of hypopituitarism should be included in the differential diagnosis of patients with central diabetes insipidus.
