TMSG-1 and its roles in tumor biology.
- Author:
Xiao-Yan XU
1
;
Fei PEI
;
Jiang-Feng YOU
Author Information
1. Peking University Health Science Center Department of Pathology, School of Basic Medical Sciences, Beijing 100191, PR China.
- Publication Type:Journal Article
- MeSH:
Animals;
Apoptosis;
drug effects;
Cell Cycle;
drug effects;
Ceramides;
chemical synthesis;
pharmacology;
Enzyme Activation;
Humans;
Membrane Proteins;
metabolism;
physiology;
Neoplasm Invasiveness;
Neoplasm Metastasis;
Neoplasms;
metabolism;
pathology;
Phosphorylation;
Sphingosine N-Acyltransferase;
metabolism;
physiology;
Tumor Suppressor Proteins;
metabolism;
physiology;
Vacuolar Proton-Translocating ATPases;
metabolism
- From:Chinese Journal of Cancer
2010;29(7):697-702
- CountryChina
- Language:English
-
Abstract:
TMSG-1 is a newly discovered tumor metastasis suppressor gene, which plays important roles in promoting apoptosis and inhibiting invasion and metastasis of tumor cells. The inhibitory function of TMSG-1 in tumor cells may be related to vacuolar H+-ATPase and ceramide, but the underlying mechanism remains unknown. Studies on TMSG-1 are limited worldwide, and only a research group in Shanghai and our group have recently studied on it. As a new research field, the function of TMSG-1 remains to be explored. This review discusses the discovery of TMSG-1, structure of its encoded protein, its roles and possible mechanism in inhibiting tumor invasion and metastasis.
