One patient with metastastic colorectal cancer successfully treated by combination of targeted agents after failure of chemotherapy.
- Author:
Liang-Ping XIA
1
;
Pei-Hong WU
;
Jian-Chuan XIA
;
Bei ZHANG
;
Zhong-Zhen GUAN
;
De-Sen WAN
;
Gui-Fang GUO
;
Yi-Xin ZENG
Author Information
1. State Key Laboratory of Oncology in South China, Guangzhou, Guangdong 510060, P. R. China.
- Publication Type:Case Reports
- MeSH:
Adenocarcinoma;
diagnostic imaging;
drug therapy;
pathology;
secondary;
Angiogenesis Inhibitors;
therapeutic use;
Antibodies, Monoclonal;
therapeutic use;
Antibodies, Monoclonal, Humanized;
therapeutic use;
Antineoplastic Agents;
therapeutic use;
Antineoplastic Combined Chemotherapy Protocols;
therapeutic use;
Bevacizumab;
Catheter Ablation;
Cetuximab;
Cytokine-Induced Killer Cells;
immunology;
Deoxycytidine;
analogs & derivatives;
therapeutic use;
Disease-Free Survival;
Drug Delivery Systems;
Fluorouracil;
analogs & derivatives;
therapeutic use;
Humans;
Immunotherapy, Adoptive;
Liver Neoplasms;
secondary;
surgery;
Lung Neoplasms;
secondary;
surgery;
Lymphatic Metastasis;
Male;
Middle Aged;
Multimodal Imaging;
Neoplasm Staging;
Positron-Emission Tomography;
Quality of Life;
Quinazolines;
therapeutic use;
Receptor, Epidermal Growth Factor;
antagonists & inhibitors;
Sigmoid Neoplasms;
diagnostic imaging;
drug therapy;
pathology;
Tomography, X-Ray Computed
- From:Chinese Journal of Cancer
2010;29(12):1023-1028
- CountryChina
- Language:English
-
Abstract:
Either cetuximab or bevacizumab can improve the survival of patients with metastastic colorectal cancer (mCRC) if administered combided with cytotoxic agents. However, the effect of two or more target agents in combination is uncertain in these patients. Here, we reported a patient with mCRC successfully treated by a combination of target agents after the failure of chemotherapy. The patient received palliative resection of primary tumor followed by 9 cycles of postoperative XELOX regimen, cytokine-induced killer cell (CIK)-based biotherapy, traditional Chinese medicine, particle implantation in the lung metastatic lesions. The tumor progressed 20 months after the standard treatments. Then, the regimen cetuximab, bevacizumab and cefitinib was applied. During the treatment with targeted agents, grade IV acne-like rash and relatively severe parionychia of the toes occurred. Both of them recovered smoothly. The PET-CT reexamination at 40 days after the target treatment showed that the metabolism of mediastinal lymph nodes basically recovered to a normal level. The combination of multiple targeted agents obtained a progression-free survival(PFS) of 11 months and the patient with a good quality of life during this period.