Synchronous occurrence of extramedullary plasmacytoma and squamous cell carcinoma in situ in the larynx: a case report.
- Author:
Xiao-Li ZHANG
1
;
Dai-Qiang LI
;
Jing-Jia LI
;
Shi-Sheng LI
;
Xin-Ming YANG
Author Information
1. Department of Otolaryngology-Head and Neck Surgery, the Second Xiangya Hospital, Central South University, Changsha, Hunan 410011, P. R. China.
- Publication Type:Case Reports
- MeSH:
ADP-ribosyl Cyclase 1;
metabolism;
Carcinoma in Situ;
diagnosis;
diagnostic imaging;
metabolism;
pathology;
surgery;
Carcinoma, Squamous Cell;
diagnosis;
diagnostic imaging;
metabolism;
pathology;
surgery;
Female;
Follow-Up Studies;
Humans;
Immunoglobulin A;
metabolism;
Immunoglobulin kappa-Chains;
metabolism;
Laryngeal Neoplasms;
diagnosis;
diagnostic imaging;
metabolism;
pathology;
surgery;
Laryngectomy;
Laryngoscopy;
Middle Aged;
Mucin-1;
metabolism;
Neck Dissection;
Plasmacytoma;
diagnosis;
diagnostic imaging;
metabolism;
pathology;
surgery;
Syndecan-1;
metabolism;
Tomography, X-Ray Computed
- From:Chinese Journal of Cancer
2010;29(12):1029-1034
- CountryChina
- Language:English
-
Abstract:
Extramedullary plasmacytoma of the larynx is rare, especially when coexisted with squamous cell carcinoma in situ. We report a 56-year-old woman with hoarseness for 6 months and dysphonia for a week. Fiberoptic laryngoscopic examination showed a red, smooth-surface swelling in the submucous region of the left ventricle and ventricular band of the larynx. The patient underwent vertical laryngectomy and modified left neck dissection. Postoperative pathologic examination revealed coexisting plasmacytoma and carcinoma in situ. Bone marrow biopsy and systemic radiogram showed no positive findings. The hepatic and renal functions were normal. Monoclonal immunoglobulin light chain of type kappa was detected in urine. Hence, a laryngeal extramedullary plasmacytoma with carcinoma in situ was diagnosed. No recurrence or progression was observed during a 2-year follow-up. Here, we discussed the risk factors, diagnosis, and therapy for this rare disease.
