MLL1/WDR5 complex in leukemogenesis and epigenetic regulation.
- Author:
Min WU
1
;
Hong-Bing SHU
Author Information
1. College of Life Sciences, Wuhan University, Wuhan, Hubei 430072, P. R. China. wumin@whu.edu.cn
- Publication Type:Journal Article
- MeSH:
Animals;
DNA Methylation;
Epigenesis, Genetic;
Histone-Lysine N-Methyltransferase;
genetics;
metabolism;
Histones;
metabolism;
Humans;
Leukemia;
genetics;
metabolism;
Lysine;
metabolism;
Multiprotein Complexes;
genetics;
metabolism;
Myeloid-Lymphoid Leukemia Protein;
genetics;
metabolism;
Transcriptional Activation
- From:Chinese Journal of Cancer
2011;30(4):240-246
- CountryChina
- Language:English
-
Abstract:
MLL1 is a histone H3Lys4 methyltransferase and forms a complex with WDR5 and other components. It plays important roles in developmental events, transcriptional regulation, and leukemogenesis. MLL1-fusion proteins resulting from chromosomal translocations are molecular hallmarks of a special type of leukemia, which occurs in over 70% infant leukemia patients and often accompanies poor prognosis. Investigations in the past years on leukemogenesis and the MLL1-WDR5 histone H3Lys4 methyltransferase complex demonstrate that epigenetic regulation is one of the key steps in development and human diseases.
