Research Progress in Escape Mutations of the Human Immunodeficiency Virus under Pressure of HLA-Restricted Cytotoxic T Lymphocytes.
- Author:
Yin SHI
;
Yanmin WAN
;
Jianqing XU
- Publication Type:Journal Article
- MeSH:
Animals;
HIV Infections;
genetics;
immunology;
HIV-1;
genetics;
immunology;
physiology;
Histocompatibility Antigens Class I;
genetics;
immunology;
Humans;
Mutation;
T-Lymphocytes, Cytotoxic;
immunology;
virology
- From:
Chinese Journal of Virology
2015;31(3):299-306
- CountryChina
- Language:Chinese
-
Abstract:
Human immunodeficiency virus type 1 (HIV-1)-specific cytotoxic T lymphocytes (CTLs) play a critical role in the control of HIV-1 infection and replication. HIV-1 evades CTL mediated pressure through viral escape mutations within targeted CTLs epitopes or flanking regions, but this process is usually associated with a viral fitness cost. The mutated epitopes may weaken the level of the original CTL responses, however, the immune system holds potential to mount denovo responses towards those newly emerged epitopes. This article briefly summarizes recent research progress regarding the competition between HIV-1's escape mutations and host CTL responses.
