Development and Application of the Reverse Genetic Technologies for Infectious Bursal Disease Virus.
- Author:
Xiaole QI
;
Yongqiang WANG
;
Li GAO
;
Honglei GAO
;
Yulong GAO
;
Xiaomei WANG
- Publication Type:Journal Article
- MeSH:
Animals;
Birnaviridae Infections;
virology;
Chickens;
Infectious bursal disease virus;
genetics;
physiology;
Poultry Products;
virology;
Reverse Genetics
- From:
Chinese Journal of Virology
2015;31(3):326-331
- CountryChina
- Language:Chinese
-
Abstract:
Infectious bursal disease virus (IBDV) is an important member of the Birnaviridae family. IBUV mainly targets the bursa of Fabricius, the central immune organ of chicken, resulting in chicken infectious bursal disease (IBD). IBD represents one of the great challenges for ongoing development of the poultry industry. Reverse genetics for IBDV emerged over twenty years ago. Since then, the technologies behind virus rescue have continually improved leading to a deep understanding of IBDV gene function and tailored vaccine development. Our lab has also been instrumental in the field of IBDV research. Here we review studies on the pathogenic mechanism and the effective prevention and control of IBD.
